Research Center Borstel
The Research Center Borstel, Leibniz Center for Biomedical Research ranks among the top research institutes for Infection Biology in Pulmonary Medicine in Europe. It hosts the German National Reference Center (NRC) for Mycobacteria which is one of the leading diagnostic centres worldwide and one of the 26 WHO Supranational Reference Laboratories (SRL). Basic, translational and clinical research issues in tuberculosis (TB) are addressed by FZB scientists and clinicians from 10 different research divisions. Their sociopolitical and distinguished scientifc mission is to carry out comprehensive health and biomedical research in pneumology, focusing especially on "infectious diseases" and "asthma and allergies", ultimately making important contributions to the development of innovate and more effective therapeutic and preventive regimens in this area.
Project coordination, scientific aspects of software and technology development, NGS parameter definition for MTBC, evaluation of new bioinformatics and sequencing tools
- Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet 2010 42 (6) : 498--503. [pmid]
- Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints. PLoS One 2009 4 (10) : e7407. [pmid]
- MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria. Nucleic Acids Res 2010 38 (Web Server issue) : W326--W331. [pmid]
- Origin, spread and demography of the Mycobacterium tuberculosis complex. PLoS Pathog 2008 4 (9) : e1000160. [pmid]